ANALYSIS OF THE EFFECTIVENESS OF SINGLE-COMPONENT AND COMBINED HEMOSTATIC AGENTS

Abstract

Stopping bleeding during operations on parenchymal organs remains an urgent and unsolved task of medicine. One of the ways to stop it is local hemostatic sponges, which contain several active components. Objective: to study the effectiveness of new experimental hemostatic sponges based on collagen with the addition of hemostatic components. Materials and methods: hemostatic activity was evaluated in an experiment on modeling profuse parenchymal bleeding on the liver and spleen in 110 rats. We studied the amount of blood loss of new hemomtatic sponges based on collagen with the addition of: cryoprecipitate 10%; cryoprecipitate and tranexamic acid; tranexamic acid 9%; chitosan and caproferr; hemoblock 2%; hemoblock 5%; hemoblock and tranexamic acid in a comparative aspect. The comparison groups were a control group, a hemostatic sponge "Belkozin", " Zelenaya dubrava" and a gauze napkin. Results: the most effective sample was hemostatic sponge with 9% tranexamic acid, the decrease in the indicator relative to the control group was 83% (387 mg) for liver injury and 79% (284 mg) for spleen injury. Conclusion: the collagen matrix is a suitable carrier for one hemostatic component. This combination makes it possible to achieve the maximum hemostatic effect and the possibility of using these experimental samples in conditions of parenchymal bleeding.