Role of andrenal influences of the prepubescent period in the development of polycystic ovary syndrome

Abstract

This article describes the case of development of secondary polycystic ovary syndrome with high activity of adrenal cortex. Young woman (19 years old) had preventive examination in private clinic. The patient revealed late menarche, 18-month amenorrhea, late development of secondary sex characteristics, but also early development of pubic and axillary hair growth and low BMI in pre-puberty years. After the first medical examination on amenorrhea patient was diagnosed with polycystic ovary syndrome. She was prescribed the combined oral contraceptive pill "Yarina". The data of the anamnesis (both vitae and morbi) and diagnostics results led to the conclusion of abnormal pre-puberty development with early thelarche. Excess adrenal activity that occurred in the period of reproductive maturing have formed the vicious circle which led to the polycystic ovary syndrome development. This case demonstrates role of non-associated with hypothalamic-hypophyseal-ovarian axis endocrine activity in female reproductive function maturation.