EXPERIMENTAL JUSTIFICATION OF THE INFLUENCE OF THE TYPE OF ENDOPROTESIS AND AUTOGEMOTHERAPY ON MORPHOFUNCTIONAL FEATURES OF GIANT MULTINUCLEAR CELLS

Abstract

In the literature there is no data on the possible involvement of giant multicore cells in the processes of regeneration of tissues surrounding the endoprostheses used in herniology in the plastics of the abdominal wall. The purpose of this study was to study the morphological features of multinucleated cells during the implantation of mesh endoprostheses in the tissue of the anterior abdominal wall. An experimental study was performed on male rabbits of the Chinsila breed. It was noted that in the early stages, multinucleated cells are localized more often on the endoprosthesis threads, then between them and later in the inner layer of the formed periprosthetic capsule. Application to the endoprosthesis of a material with an antimicrobial or antibacterial coating, as well as the simultaneous introduction of autoplasma enriched with platelets under the endoprosthesis leads to the appearance in the periprosthetic tissues of morphologically different types of multicore cells.