innjoInnovaInnova2500-2937КГМУinnjo-57Research ArticleСтатьи«ШЕЕВСКИЕ» ПОРАЖЕНИЯ СЛИЗИСТОЙ ОБОЛОЧКИ ЖЕЛУДКА В ЭКСПЕРИМЕНТАЛЬНОМ МОДЕЛИРОВАНИИ: АКТУАЛЬНОСТЬ И ПЕРСПЕКТИВЫ (ОБЗОР ЛИТЕРАТУРЫ)SHAY'S LESIONS OF THE GASTRIC MUCOSA IN EXPERIMENTAL SIMULATION: THE RELEVANCE AND PROSPECTS (LITERATURE REVIEW)ПриваловаИ. Л.PrivalovaI. L.noemail@neicon.ruВолобуевР. В.VolobuevR. V.noemail@neicon.ruКурский государственный медицинский университетРоссияKursk State Medical UniversityRussian Federation202018082021011316Copyright © Привалова И.Л., Волобуев Р.В., 20212021Привалова И.Л., Волобуев Р.В.Privalova I.L., Volobuev R.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innova-journal.ru/jour/article/view/57

Проведен аналитический обзор исследований с использованием лигирования привратника у крыс по H. Shay для моделирования острого поражения слизистой оболочки желудка. Приведено обоснование метода, подробно описана техника его выполнения и методика оценки результатов. В работе обсуждается научная ценность метода лигирования привратника у крыс в эксперименте, а также современные аспекты его использования.

An analytical review of studies using the ligation of pylorus in rats by Shay for simulation acute lesions of the gastric mucosa was conducted. The substantiation of the method is given, the method of its implementation and the method of evaluation of the results are described in detail. The article discusses the scientific value of the method of ligation the pylorus in rats in the experiment, as well as modern aspects of its use.

экспериментальное моделированиеострое повреждениеслизистая оболочка желудкалигирование привратника у крысexperimental modelingacute injurygastric mucosapylorus ligation in ratsReferencesЦиммерман, Я.С. Гастродуоденальные эрозии: современное состояние проблемы / Я.С. Циммерман // Клиническая медицина. - № 1. - 2012.Циммерман, Я.С. Гастродуоденальные эрозии: современное состояние проблемы / Я.С. Циммерман // Клиническая медицина. - № 1. - 2012.Экспериментальное моделирование в гастроэнтерологии. Практические рекомендации. Часть II. Экспериментальные модели «острых» язв желудка /А. И. Багинская [и др.] // Вопросы экспериментальной биологии и медицины. - 2016. - 35 с.Экспериментальное моделирование в гастроэнтерологии. Практические рекомендации. Часть II. Экспериментальные модели «острых» язв желудка /А. И. Багинская [и др.] // Вопросы экспериментальной биологии и медицины. - 2016. - 35 с.A study of the effects and mechanism of action of sodium dodecyl sulphate on gastric secretion in rats / S.A. Komarov [et all] // Pharmacology. - 1950.A study of the effects and mechanism of action of sodium dodecyl sulphate on gastric secretion in rats / S.A. Komarov [et all] // Pharmacology. - 1950.Drug Discovery and Evaluation: Pharmacological Assays / H.G. Vogel [et all]. - Aalen: Springer, 2008. - 2071 c.Drug Discovery and Evaluation: Pharmacological Assays / H.G. Vogel [et all]. - Aalen: Springer, 2008. - 2071 c.Aguwa, C. N. Antiulcer effects of trimipramine using various laboratory models / C.N. Aguwa, T.R. Pamanyam // Japanese journal of pharmacology. - 1984.Aguwa, C. N. Antiulcer effects of trimipramine using various laboratory models / C.N. Aguwa, T.R. Pamanyam // Japanese journal of pharmacology. - 1984.Aguwa C. N. Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat / C. N. Aguwa // European journal of pharmacology. - 1984. - № 114. - С. 79-84.Aguwa C. N. Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat / C. N. Aguwa // European journal of pharmacology. - 1984. - № 114. - С. 79-84.Gastric antisecretory and antiulcer activity of bovine hemoglobin / Al Asmari Abdurahman [et all] // World Journal of Gastoenterology. - 2013. - № 19. - С. 3291-3299.Gastric antisecretory and antiulcer activity of bovine hemoglobin / Al Asmari Abdurahman [et all] // World Journal of Gastoenterology. - 2013. - № 19. - С. 3291-3299.McAlpin, C. D. Gastric histamine metabolism after acute pyloric ligation in the Shay rat / C.D. McAlpin, T.C. Moore, C.A. Lammi // Archives of sergery. - 1974. - № 109.McAlpin, C. D. Gastric histamine metabolism after acute pyloric ligation in the Shay rat / C.D. McAlpin, T.C. Moore, C.A. Lammi // Archives of sergery. - 1974. - № 109.Radwan, A.G. Effect of aminogusnidine, chlorpromazine and NSD - 1055 on gastria secretion and ulceration in the SHAY rat [Электронный ресурс]/ A.G. Radwan, G.B. West// British Journsl Pharmacology. - 1971. - C. 167-169.Radwan, A.G. Effect of aminogusnidine, chlorpromazine and NSD - 1055 on gastria secretion and ulceration in the SHAY rat [Электронный ресурс]/ A.G. Radwan, G.B. West// British Journsl Pharmacology. - 1971. - C. 167-169.Tabuchi, Y. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats / Y. Tabuchi, Y. Kurebayashi // Japanese journal of pharmacology. - 1992.Tabuchi, Y. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats / Y. Tabuchi, Y. Kurebayashi // Japanese journal of pharmacology. - 1992.Blair, D.W. Effect of L-thyroxine on gastric secretion in the pylorus-ligated rat / D.W. Blair, M.I. Williams, A.I. Carr, S.I. Kilpacridi // Departaments of Surgery, Materia Medica and Therapeuticus, Pathology and Statistics University of Aberdeen. - 1965.Blair, D.W. Effect of L-thyroxine on gastric secretion in the pylorus-ligated rat / D.W. Blair, M.I. Williams, A.I. Carr, S.I. Kilpacridi // Departaments of Surgery, Materia Medica and Therapeuticus, Pathology and Statistics University of Aberdeen. - 1965.Gastroprotective effect of minocycline in experementally induced gaster ulcers in rats / Al Asmari Abdurahman [et all] // International Journal of clinical and experimental medicine. - 2014.Gastroprotective effect of minocycline in experementally induced gaster ulcers in rats / Al Asmari Abdurahman [et all] // International Journal of clinical and experimental medicine. - 2014.Tuorkey M.J., Abdul Aziz K.K. A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pylorus [corrected] ligation model (Shay model) / M.J. Tuorkey, K.K. Abdul Aziz// Biomedcine & Pharmacotherapie. - 2008.Tuorkey M.J., Abdul Aziz K.K. A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pylorus [corrected] ligation model (Shay model) / M.J. Tuorkey, K.K. Abdul Aziz// Biomedcine & Pharmacotherapie. - 2008.Interferon-inducer polyriboinosinic-polyribocytidylic acid: a potent anti-gastric ulcer agent and inhibitor of the gastric proton pump in rats / C. Nath [и др.] // Clinical and experemetal pharmacology & physiology. - 2002.Interferon-inducer polyriboinosinic-polyribocytidylic acid: a potent anti-gastric ulcer agent and inhibitor of the gastric proton pump in rats / C. Nath [и др.] // Clinical and experemetal pharmacology & physiology. - 2002.Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats / J. Tanaka [и др.] // Arztneimittel - Forschung, - 2004.Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats / J. Tanaka [и др.] // Arztneimittel - Forschung, - 2004.Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats / R.H.L. Souza [и др.] // DARU Journal of Pharmaceutical Scienes. - 2011. - № 19. - 277-281.Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats / R.H.L. Souza [и др.] // DARU Journal of Pharmaceutical Scienes. - 2011. - № 19. - 277-281.Huilgol, S.V. Evaluation of antiulcerogenic potential of atitoxidant a-tocopherol IN pylorus-ligated / S.V. Hugol, V.H. Kumar // Journal of basic and clinical physiology and pharmacology. - 2014.Huilgol, S.V. Evaluation of antiulcerogenic potential of atitoxidant a-tocopherol IN pylorus-ligated / S.V. Hugol, V.H. Kumar // Journal of basic and clinical physiology and pharmacology. - 2014.Konteiro K.M. Characterization of a refinement of the "pylorus ligation" model of rat gastric ulceration resulting in "no pain" and a more specific pharmacological response / K.M. Konteiro [и др.] // Journal of pharmacological and toxilogical methods. - 2013.Konteiro K.M. Characterization of a refinement of the "pylorus ligation" model of rat gastric ulceration resulting in "no pain" and a more specific pharmacological response / K.M. Konteiro [и др.] // Journal of pharmacological and toxilogical methods. - 2013.Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities / XY Wang [и др.] // Carbohydrate polymers. - 2018.Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities / XY Wang [и др.] // Carbohydrate polymers. - 2018.Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats / T. Al. Howiriny [et all] // Journal of ethnopharmacology. - 2005.Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats / T. Al. Howiriny [et all] // Journal of ethnopharmacology. - 2005.Garcia Barrantes P.M. Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models / P.M. Garcia Barrantes, B. Badilla // Journal of ethnopharmacology. - 2011.Garcia Barrantes P.M. Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models / P.M. Garcia Barrantes, B. Badilla // Journal of ethnopharmacology. - 2011.Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats / A. J. Al. Rahaily [et all] // Phytomedicine: international journal of phytotherapy and phytopharmacology. - 2002.Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats / A. J. Al. Rahaily [et all] // Phytomedicine: international journal of phytotherapy and phytopharmacology. - 2002.Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. Indicus / A. Anoop, M. Jegadeesan // Journal of ethnopharmacology. - 2003.Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. Indicus / A. Anoop, M. Jegadeesan // Journal of ethnopharmacology. - 2003.Acid-gastric antisecretory effect of the ethanolic extract from Arctium lappa L. root: role of H+, K+-ATPase, Ca2+ influx and the cholinergic pathway / L.M. Da Silva [et all] // Inflammopharmacology. - 2017.Acid-gastric antisecretory effect of the ethanolic extract from Arctium lappa L. root: role of H+, K+-ATPase, Ca2+ influx and the cholinergic pathway / L.M. Da Silva [et all] // Inflammopharmacology. - 2017.Evaluation of Antiulcer Activity of Peltophorum Pterocarpum / B. Pradeepkumar [и др.] // Journal of clinical and diagnostic research: JCDR. - 2017.Evaluation of Antiulcer Activity of Peltophorum Pterocarpum / B. Pradeepkumar [и др.] // Journal of clinical and diagnostic research: JCDR. - 2017.Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats / V.C. Devaraj [и др.] // Saudi Pharmaceutical Journal. - 2011. - № 19. - C. 171-176.Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats / V.C. Devaraj [и др.] // Saudi Pharmaceutical Journal. - 2011. - № 19. - C. 171-176.

The authors declare that there are no conflicts of interest present.